X-Linked Tremors

Category:

Nervous system / Neurologic - Associated with the brain, spinal cord and nerves

Gene:

PLP1

Variant Detected:

A>C on X chromosome

Severity:

Moderate-Severe. This is a disease with significant welfare impact on the affected animal, in terms of clinical signs and generally reduced life expectancy.

Mode of Inheritance:

Autosomal X-Linked

Research Citation(s):

Nadon, N. L., Duncan, I. D., & Hudson, L. D. (1990). A point mutation in the proteolipid protein gene of the “shaking pup” interrupts oligodendrocyte development. Development

Associated Breed(s):

Mixed breed,